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The mechanisms underlying these cardioprotective effects are not fully elucidated but likely involve multiple pathways

Semaglutide reduces atherosclerotic cardiovascular disease risk by approximately 26% in high-risk populations, while statins reduce low-density lipoprotein cholesterol by 3050% depending on potency and dose

In one study, the infusion of GLP-1 and GIP increased plasma insulin levels by 4.1 and 3.6 times, respectively, compared to a saline infusion in healthy subjects during a hyperglycemic clamp procedure [10]