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[6] [7] It is taken by mouth, injection into a muscle, or injection into a vein

Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues

In the context of limited glutamine, various cell components in the TME compete for glutamine, and tumor cells can increase their uptake of glutamine due to their unique metabolic mode, thus providing certain competitive advantages

After reconstitution, the solution should be stored at 2 to 8 degrees Celsius and used within 28 days