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& Hool, A

doi: 10.1002/jimd.12475 18

Taken together, these findings suggest that subclinical reactivation of HSV-1 in the brain of patients with AD may promote increased deposition of A in this tissue, thus accelerating disease progression

While some ROS generation, produced via NADPH-dependent NOX and iNOS, is advantageous and necessary for pathogen clearance, it must be carefully titrated by antioxidant GSH which is itself regulated by NADPH-dependent glutathione reductase