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GLP-1, but not metformin, significantly ameliorated AMPK activator- or MG-induced cell death and apoptosis We administered different concentrations of AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR, 0.5, 1, 1.5, and 2 mM) to RINm5F cells and then incubated for 2, 4, 6, 17, and 24 h, respectively
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Results indicate that Rybelsus can lead to significant weight loss even in non-diabetic individuals, but it should only be used under medical supervision
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