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The original Achilles tendon transection model in rats (Staresinic, Sikiric et al., 2003) showed that systemic BPC-157 accelerated healing of fully transected tendons, and this finding has been reproduced across multiple labs over the 20+ years since
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In practice, the long-acting GLP-1 RAs became preferred for general glycemic control due to convenience and greater A1c reduction, whereas short-acting ones like lixisenatide found a niche in combination products or for targeting post-meal glucose excursions (for instance, some use lixisenatide mainly to handle breakfast hyperglycemia)
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