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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

Digestive enzymessuch as pancreatic enzyme replacement therapies (e.g., pancreatin products like Creon or Pancrex) or over-the-counter supplements containing amylase, lipase, and proteaseare typically used to support digestion in individuals with pancreatic insufficiency, chronic pancreatitis, or certain malabsorption disorders

However, implementing such approaches requires careful evaluation of evidence quality and vigilant monitoring for herbdrug interactions