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49 A three-month, randomized, controlled trial in 50 peri- and postmenopausal women reported a combination of black cohosh, vitex, red clover, dong quai, American ginseng ( Panax quinquefolius ), and milk thistle ( Silybum marianum ) led to a 73% reduction in hot flashes and 69% reduction in night sweats

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[29] Supplementation does not appear to have an effect in infants with significant stomach or intestinal disorders

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