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Several GLP-1 RAs have additional FDA approval for: Heart protection : Dulaglutide [archived link], liraglutide [archived link], and semaglutide [archived link] have been proven to prevent strokes and heart attacks in people with risk factors, such as diabetes or obesity

( Peptide InnOvatioN for the Early diabetEs tReatment (PIONEER) trial showed that GLP-1RAs caused an overall nausea rate of 15-20% and were associated with gastrointestinal adverse events, but these were temporary and dose-dependent ( Underlying mechanism The mechanisms that contribute to the beneficial effects of SGLT2i and GLP-1RAs in patients with T2DM have been extensively studied