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Similarly, in patients with obesity-related HFpEF (Heart Failure with Preserved Ejection Fraction), semaglutide produced substantial improvements in symptoms and exercise capacity [46]
The changes can resemble what happens during menopause, when estrogen decline contributes to rapid collagen loss, thinning skin, and impaired barrier function
These effects were mediated by the upregulation of M 2 receptors and the downregulation of 1 -adrenergic receptors
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