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GSH synthesis and consumption The synthesis of GSH relies on cysteine as the starting material, and cellular resistance to lipid oxidation depends on intracellular cysteine levels, primarily produced by the system Xc and transsulfuration pathways

The MASH/liver Phase 3 studies On the liver side, the program includes a Phase 3 trial in non-cirrhotic MASH with F2F3 fibrosis (LIVERAGE, NCT06632444) and a study in participants with compensated MASH cirrhosis (LIVERAGE-Cirrhosis, NCT06632457), the latter evaluating liver-related clinical outcomes over a multi-year horizon

85.7%, p = 0.68), HDL cholesterol and LDL cholesterol levels were higher in ALT responders