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The increase in the anabolic threshold with ageing could be explained by many factors associated with ageing such as inflammation, insulin resistance or oxidative stress that have all been shown to lower the muscle anabolic response following food intake ( Reference Dardevet, Remond and Peyron 49 , Reference Boirie 65 )
Psychiatry 164 (10), 15851592
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Additionally, weight reduction decreases mechanical stress on weight-bearing joints, potentially alleviating painthough this effect may be more relevant to osteoarthritis than to the autoimmune processes of RA
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