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One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy, Appetite, 227 , (108723), (2026)
For approved SGLT2 inhibitors there is on average some 1.52 kg weight loss (placebo-adjusted), for GLP1-RAs 24 kg, and for the combination 35 kg [1723]
During public testimony, patients and practitioners described perceived benefits and the difficulty of accessing products through regulated channels
doi:10.1371/journal.pone.0253298
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