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The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
The NHS reports that severe calorie restriction, such as with anorexia, bulimia, or similar eating disorders, sends a message to your brain to stop producing the hormones needed for ovulation (and if you dont ovulate, you wont have a true period, though you may still experience some vaginal bleeding)
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Other repeated body-focused symptoms, such as biting ones fingernails, are common among people with trichotillomania
