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The Croatian Phase I and II clinical trials for inflammatory bowel disease conducted in the 1990s by pharmaceutical company Pliva claimed safety with no significant toxicity, though complete peer-reviewed data never appeared in scientific literature beyond conference abstracts
After this point, both peptide degradation and bacterial contamination risk increase beyond acceptable thresholds, even with bacteriostatic water as the diluent
Male factors contribute to around 50 % of the overall cases of infertility
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