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Being a water-soluble nutrient, it may get excreted out of the body by way of urine in case of excess
In 1870, British gastroenterologist Samuel Fenwick (1821-1902) in London associated stomach atrophy with this form of anemia and demonstrated that stomach mucosa from an affected fresh cadaver could not digest boiled egg white with prolonged incubation, whereas mucosa from a control stomach could do this (139)
Overall, Hycomin provides a practical injectable vitamin B12 option for professional use, offering a stable hydroxocobalamin formulation that can be incorporated into various mesotherapy or skin-focused treatment protocols where structured administration and compatibility with combination approaches are required.
It was developed for research by Professor Predrag Sikiric at the University of Zagreb
