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The math also favors multiple cycles
Remarkably, the overexpression of PGC-1 fostered the increase of Glutathione S-transferases (Gstt, Gstp), involved in the detoxification of NAPQI by conjugation with GSH (Fig
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In summary, FSP1-CoQ10-NADPH forms an independent parallel defense system, complementing the classical glutathione-GPX4 pathway to inhibit phospholipid peroxidation and block ferroptosis
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