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It is the target for several FDA-approved antidiabetic medications called incretin mimetics: These incretin mimetics are glucagon-like peptide 1 (GLP-1) analogs that mimic the physiological action of GLP-1 and thereby potentiates the incretin effect in type 2 diabetic patients

Mechanistically, GLP-1 receptor agonists improve endothelial function, cause vasodilation, reduce systemic vascular resistance, lower blood pressure, reduce inflammation, and favorably affect lipid profiles

It is indicated for adults with obesity (BMI of 30 kg/m^2 or greater) and adults who are overweight (BMI of 27 kg/m^2 or greater) with at least one weight-related medical condition, such as high blood pressure, T2D, or dyslipidemia

Benefits appear within the first few weeks and then increase synergistically with continued treatment