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Tissue-related and structural pathway dynamics

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A provider prescribing tirzepatide for a patient with type 2 diabetes uses Mounjaro and codes to diabetes diagnosis codes

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In the emulation of SURPASS-CVOT comparing tirzepatide to dulaglutide in patients at high cardiovascular risk (Table 2 and Supplementary Table 19), the estimated HR was 0.83 (95% CI 0.69 to 1.01) compared to the trial estimates of HR 0.92 (95% CI 0.83 to 1.01)

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Study limitations include that it was only conducted in a subset of the original 2,539 SURMOUNT-1 participants

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