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Collectively, current evidence from RCT subgroups, observational studies, and mechanistic data supports the biological plausibility and clinical relevance of complementary cardiovascular and kidney benefits with combined SGLT2i and GLP-1RA therapy (Table 2)

Excess dietary L-cysteine, but not L-cystine, is lethal for chicks but not for rats or pigs

It is well-tolerated with essentially no side effects, making it an attractive option for patients who prefer non-pharmacological approaches

The most common adverse events were dose-related gastrointestinal symptoms, primarily nausea, which were previously seen with GLP-1 receptor agonists