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Toxicity and efficacy evaluation of an adeno-associated virus vector expressing codon-optimized RPGR delivered by subretinal injection in a canine model of X-linked retinitis pigmentosa
The nasal spray format enables intranasal delivery research
In animal studies, it affects angiogenesis (blood vessel formation), collagen organization, and growth factor modulation through pathways including EGR-1 gene upregulation
In addition, recent clinical evidence from the AngioSafe T2DM Study demonstrated no association between GLP-1 RAs and severe diabetic retinopathy [107], suggesting that GLP-1 RA does not have a causal influence on retinopathy independent of glucose lowering
