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Participants with unknown or declined racial status were less likely to respond than their white counterparts (0.253 [0.1440.445])

2022;doi:10.1001/jama.2021.23619

This article explores the biological reasons for tiredness during treatment, from caloric deficits to metabolic shifts

Per FDA pharmacokinetic data, hepatic impairment reduces escitalopram oral clearance by 37% and approximately doubles the elimination half-life, extending full clearance to approximately two weeks in affected patients