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Signs you need medical attention Get medical help right away if you have: Severe stomach pain that might spread to your back (possible pancreatitis) Neck lumps or swelling, hoarse voice, trouble swallowing (possible thyroid tumors) Severe allergic reaction signs, including rash, swelling, and breathing problems Low blood sugar symptoms: dizziness, confusion, sweating, shakiness Gallbladder problems: severe stomach pain, fever, yellow skin/eyes Changes in vision or kidney problems Wrong doses can lead to severe side effects that may need hospital care

Patients who skip the break period and run continuous cycles do not get proportionally better outcomes and risk diminishing returns on the therapeutic response

However, mechanistic reasoning suggests potential complementarity

Their model, which is much simpler than ours in that it does not contain detailed liver biochemistry, is sufficient for predicting patient outcomes