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Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis

Available from Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration