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An extreme example of the effects of GCG on lean mass is in individuals with glucagonoma, which is characterised by very high levels of circulating GCG, low levels of amino-acids, and sarcopenia [61, 62]
PMID 7492947
Rodbard HW, Lingvay I, Reed J, de la Rosa R, Rose L, Sugimoto D, Araki E, Chu PL, Wijayasinghe N, Norwood P
Those studies revealed that GLP-1RA can act directly and indirectly in the arterioles and capillaries and increase microvascular perfusion [34,35,36]
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