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Major Reclassification : This detailed, stepwise procedure applies to applications that break new ground, such as a new type of medicine or condition being considered for a classification change

Alterations of circadian rhythms and their impact on obesity, metabolic syndrome and cardiovascular diseases

However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)