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Likewise, anti-inflammatory actions of IGF-1 [124] can be regarded as a crucial factor protecting tissues from the deleterious effects of pro-inflammatory mediators in chronic disorders such as obesity

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Paracetamol is a suitable first-line alternative for mild to moderate pain, whilst topical NSAIDs (such as ibuprofen gel) provide localised relief for musculoskeletal conditions with minimal systemic absorption and reduced gastrointestinal risk compared to oral NSAIDs

Odhett Cojocaru, MD