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The participants either took a placebo, or a weekly 5 milligram (mg), 10 mg, or 15 mg tirzepatide injection for a year, depending on how much they could tolerate

Discontinuation rates due to adverse effects were also higher with retatrutide being 16-17% compared with 2% with dulaglutide and 0-4% with placebo

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Our prior work revealed a role for the adipocyte circadian clock in regulating energy balance according to the time when an animal eats through control of creatine-mediated thermogenesis 8