As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]
However, the lasting effects of these injections can vary significantly between individuals, influenced by factors such as overall health, the severity of the deficiency, and the bodys absorption capacity
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If your BMI is below 27, it might be better to focus on losing weight without medication and on developing healthier, sustainable habits