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Future trials should be structured to assess whether initiating treatment in high-risk, cognitively unimpaired individuals (e.g., those with type 2 diabetes mellitus, obesity, and/or specific genetic risk factors such as APOE4) can delay or prevent cognitive decline onset
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The rising incidence of T2DM globally has further boosted the adoption of GLP-1 receptor agonists, especially as healthcare providers increasingly recommend these drugs due to their unique therapeutic benefits
Patients may start treatment due to affordability but discontinue once costs accumulate or expectations are not met
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