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Search strategy We used the following search strategy: (irritable bowel syndrome OR IBS OR spastic colon OR irritable colon) AND (Glucagon like peptide 1 receptor agonist OR GLP-1 agonist OR Semaglutide OR Dulaglutide OR Exenatide OR Liraglutide OR Lixisenatide OR Tirzepatide)
Roose SP, Rutherford BR, Wall MM, Thase ME
doi: 10.1016/S0168-8278(22)01680-4 27
Pharmacokinetics of IGF-1 LR3 The extended half-life of IGF-1 LR3 stems from two features: the N-terminal extension physically blocks IGFBP binding, and reduced clearance via the IGFBP-ALS ternary complex slows hepatic filtration
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