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Samples were centrifuged at 12,000 g for 10 min at 4 C, and the supernatant was transferred to a pulled insert in a vial for subsequent analysis (Clark et al., 2017)
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however, the progression from low-grade PanINs to PDAC involves sustained proliferation leading to the accumulation of somatic mutations and typically spans for longer than a decade 20,31
once the dosage form passes these regions, no further absorption occurs, regardless of the drug release rate
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