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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations
In this complex, both, the FOXO4-derived region and the cationic cell permeability peptide contribute to the interaction
These mechanisms have been substantiated in animal model studies
This dual potential of enhancing antioxidant defense and possibly boosting telomere integrity might explain some of the lifespan-extending actions hypothesized in epithalamin and Epithalon models
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