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How Fast Does GLP-1 Work How Long Can You Take GLP-1 How Long Does GLP-1 Stay in Your System Here are a Few Other Conditions That Might Mean GLP-1 Therapy Isnt Right for You The following conditions may indicate that GLP-1 therapy is not appropriate: Thyroid cancer risk Personal or family history of medullary thyroid carcinoma (MTC): GLP-1 medications have been associated with a slightly increased risk of developing MTC, a type of thyroid cancer