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An effect was observed at T0 before the glucose challenge but already after 30 min (60 min after dosing) there was no significant effect on the blood glucose for peptide 1 in agreement with previous IPGTT study
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The clinician chooses semaglutide, drawing insights from landmark trials (including data from the LEAD study on liraglutide and parallel findings with semaglutide) (16)
This makes bedtime dosing optimal, as it amplifies the natural nocturnal GH surge without disrupting the diurnal secretory rhythm
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