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Journal of applied physiology (Bethesda, Md

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At baseline, they had an average of 4 DSM-5 alcohol use disorder symptoms (consistent with moderate severity), consumed alcohol 20/28 days and 9/28 days with heavy drinking (4+ for women and 5+ for men each day)

in Spain, its current prevalence ranges between 2833%11,12 and it is a recognized as a cardiovascular risk factor and increases the mortality in this population.1315 Furthermore, in patients with DM2 and advanced CKD there are limitations in the prescription of certain antihyperglycemic drugs (e.g., metformin or sulfonylureas) and there is an increased risk of hypoglycemia with antihyperglycemic treatment,16 a complication that is associated with increased cardiovascular risk17 and hinders the achievement of glycemic control targets