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19 The insulin resistance increases with gestational age and may be exacerbated when coupled with prolonged fasting in the second and third trimesters

Intranasal administration avoids the BBB by using the olfactory and (to a lesser extent) trigeminal nerves, offering a direct corridor to the brain, thus improving the chances of successful therapeutic outcomes (54)

This is similar to chronic inflammatory response syndrome (CIRS) seen with mold and Lyme disease

These effects result from growth hormone and IGF-1s anabolic effects on muscle tissue, including enhanced protein synthesis, reduced protein breakdown, increased satellite cell start, and improved nutrient partitioning toward muscle