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TABLE 2 Neuroprotective role of phytochemicals via management of oxidative stress

Similarly, niacinamide concentrations should not exceed 10% for periorbital use versus 15-20% sometimes used on face, and retinoids if included should be present only in gentle forms at low concentrations to avoid significant irritation

found that the ketone bodies, especially -hydroxybutyrate, which protects against lipotoxicity and stimulates lipid oxidation, was significantly elevated in obese subjects (28)

These include increased oxidative stress, environmental exposures, chronic stress, poor sleep, nutritional gaps, and the natural ageing process