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Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)
J Cell Mol Med 2024;28:e18243
Summary Keywords glutathione, oxidative stress, reactive oxygen species, nuclear factor erythroid 2-related factor 2, inflammaging, chronic obstructive pulmonary disease, atherosclerosis, COVID-19 Citation Labarrere CA and Kassab GS (2022) Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
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