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The LC-MS data included some missing values, which were handled as follows: if the missing values accounted for more than 20% of samples, the metabolite was excluded from the analysis

Initial analysis of our RNA-seq dataset comparing melatonin- and vehicle-treated ILC2s revealed broad suppression of pro-inflammatory gene expression following melatonin treatment, including canonical type 2 cytokines such as Il5 , Il13 , and Csf2