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Some investigations have demonstrated that the two compounds, acting as agonists of the GSH antioxidant system, well prevent oxidative stress and reduce heart damage in some animal cardiomyopathy models, for instance, the ISO-induced myocardium infarction model [159, 160]
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Further adequately powered prospective studies are required before combined SGLT2 inhibitor and GLP-1 receptor agonist therapy can be routinely recommended, specifically to improve heart failure outcomes
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