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Subsequent O 2 binding yields an Fe(III)-superoxo species that is in resonance with a formulation in which the coordinated sulfur bears a partial radical character
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Cycle Duration and Monitoring Typical cycle: 1224 weeks Monitoring: baseline and 1012 week IGF-1 measurement is the most common biomarker Washout: 48 weeks between cycles is standard practitioner practice Contraindications Active malignancy GH/IGF-1 axis elevation is a theoretical oncogenic concern Diabetes mellitus GH elevates insulin resistance
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