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The COMBO-DN study was a large, double-blind, randomized clinical trial that compared the efficacy and safety of high-dose monotherapy versus combination therapy with duloxetine and pregabalin in patients with DPN who had not responded to standard doses [126]

Large controlled trials in general athletic populations havent confirmed these effects definitively, so its best framed as a supportive tool within a broader recovery protocol, not a performance guarantee

Instead they activate different receptors either in the anterior pituitary gland or in the hypothalamus of the animal