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Solid filamentation assays were completed in triplicate and assessed at 3-, 4-, 5-, and 6-hour timepoints using EVOS microscope at 10X magnification

Stepping down from 2.4 mg to 1.7 mg, or even further to 1 mg, may resolve symptoms while maintaining some of the metabolic benefits of the medication

Differential Diagnosis Hyperpigmented macules or patches that might be confused with CALMs include pigmentary mosaicism (segmental pigmentation disorder, linear nevoid hyperpigmentation), early nevus spilus (before the speckles have appeared), Becker melanosis (without obvious hypertrichosis), mastocytoma, mosaic (segmental) neurofibromatosis, and postinflammatory hyperpigmentation

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