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Early-phase clinical trial data, including results from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), demonstrated significant weight reduction in adults with obesity (without type 2 diabetes), with participants receiving the highest dose losing a mean of approximately 24% of their body weight over 48 weeks

The major interaction risk for sermorelin is with glucocorticoids, which blunt GH secretory response and reduce protocol efficacy

Combining multiple GLP-1 agonists simultaneously is not recommended

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