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What the Evidence Shows So Far Preclinical Promise A major review of preclinical research mainly in cell cultures and animal models found that most GLP1 drugs significantly reduced amyloidbeta and tau accumulation and appeared to improve insulin signalling and reduce brain inflammation

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Rybelsus is approved for type 2 diabetes, and the Wegovy pill was approved in December 2025 for weight loss at a higher dose

Before starting treatment, patients should carefully review their medical history and discuss potential side effects with their provider