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Collectively, these findings provide a mechanistic rationale for developing multi-target agonists: GLP-1R appears to provide the most potent and direct anti-MASLD and anti-fibrotic effects in the liver, while GIPR and GCGR offer complementary benefits for glucose and lipid metabolism, with GIPR also exhibiting superior cardiovascular protection

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These products are readily available online and often falsely labeled as being intended for research use only or for licensed researchers, despite being widely marketed to and purchased by the general public