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10.1111/j.1440-1681.2008.05029.x

Blood-brain delivery methods using nanotechnology

Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

Heres how coffee enemas are thought to benefit the liver: Bile Duct Stimulation : Coffee, when administered rectally, is absorbed through the walls of the colon and stimulates the liver to produce bile, which is a natural detoxifier