Site Rotation: How to Track It and Why It Matters Injecting repeatedly into the same spot causes lipodystrophy, a breakdown of subcutaneous fat that creates permanent indentations and can impair peptide absorption at that site
Pharmacogenetics 5(5):298304 Mai Y, Dou L, Yao Z, Madla CM, Gavins FKH, Taherali F et al (2021) Quantification of P-glycoprotein in the gastrointestinal tract of humans and rodents: methodology, gut region, sex, and species matter
Bile production and secretion The liver synthesizes and stores glycogen, which is a way to keep a glucose reserve for the "long term." Glycogen storage In addition to its roles in glucose storage and producing bile for fat metabolism, the liver also helps produce and break down amino acids as well as synthesize cholesterol
When youre losing fat actively, the bodys demand for the cofactors that drive metabolism (including B12, B6, folate) goes up while supply goes down