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This binding reduces calcium influx at presynaptic nerve terminals and blunts the release of excitatory neurotransmitters including glutamate, norepinephrine, and substance P
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& Gao, B
Its hopes of turning around the fortunes of the ITCA 650 implant, designed to continuously deliver exenatide over six months, were dashed, however, when the committee voted 19 to nothing that the benefits of the product do not outweigh its risks
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