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Proliferation (log 2 doublings, 5 days) of Karpas299 cells transduced with a sgControl or sg VCAN under the indicated concentrations of ML162

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The authors reported a 55.8% reduction in facial wrinkle volume and a 32.8% reduction in wrinkle depth compared with control serum, alongside in vitro evidence that GHK-Cu increased both collagen and elastin production in human dermal fibroblasts at concentrations as low as 0.01 nM [4]

2000 Sep-Dec;22(5-6):384-92